Process equipment sanitation and CIP

Sanitation and disinfection of process equipment with ozone

Throughout the industrial sector, food & beverage, dairy facilities, process industry and pharmaceutical plants, major amounts of water, energy and chemicals are spent in order to maintain clean and sanitized process equipment. Equipment such as tanks, pipes, valves, heat exchangers and filling machines need to be kept free from unwanted microorganisms, biofilm, scale and chemical residues. Failure to maintain clean process equipment may lead to the following:

  • Spoiled final product
  • Inefficient heat exchangers
  • Heavy maintenance
  • Increased demand on chemicals, water & energy


CIP basics

Clean-in-Place (CIP) is one of the most common unit operations throughout the industrial sector and is crucial in order to clean process equipment between different batches. Today, these processes are fully automatic with central CIP stations installed which serve the whole plant's process equipment cleaning and sanitation needs. They enable cleaning cycles inside pipes and tanks which are otherwize inaccessible for plant staff. Typically it includes the following steps:

Typical CIP phases in process equipment cleaning and sanitation.

CIP cycle stepPurposeCleaning agentChallenges
1. Pre-rinseRemove majority of particles, organic material before cleaning agent.Water.High water demand, wastewater loads.
2. Caustic or acid cleaningClean organic material and particles which have adhered to internal surfaces. Acid cleaning may also remove inorganic particles to avoid scaling. Remove surfaces that enhance microbial growth.Sodium or potassium hydroxide, various acids.Chemical handling, costly.
3. RinseRinse away caustic or acid in order to avoid product contamination.Water.High water demand, wastewater loads.
4. Sanitation & disinfectionEnsure microbial (bacteria, viruses, algae) free process equipment. Even a few microbes may cause infections of final product.Chlorine based agents, peracetic acid (PAA), hot water, steam, iodophores.Ensuring complete removal of bacteria. High costs.
5. Final rinseRinse away sanitation chemicals to avoid contamination of brew.Water.Adds time and water consumption to the CIP cycle.

Ozone CIP

Ozone technology presents a novel approach to sanitizing process equipment with significantly lower water, chemicals and energy demand. Ozone completely replaces costs and handling of traditional sanitation methods using chemicals or hot water. Ozone leaves no residual chemicals after use which means final rinse is not required. It is also possible to apply ozone directly following cleaning - ozone rinsing. This enables a 3-stage CIP instead of 5 cycles. The figure below illustrates CIP improvements that can be made by replacing chemicals and utilizing the unique characteristics of ozone. It shows how a 5-stage CIP cycle can be reduced to a 4-stage cycle.

Ozone CIP brewery benefits

Hot water sanitation is commonly used where chemical use is to be avoided. However, it is time consuming and exerts strain on forces on the mechanical equipment during expansion and contraction during heating and cooling. Since ozone leaves no residues, it is a viable cold sanitation method in lieu of hot water use, which saves major amounts of energy and associated costs. This concept is illustrated below.

Replacing hot water CIP with ozone

Ozone is produced in-situ and on demand, which means that it is generated and applied when it is needed. This is the key characteristic of ozone compared traditional chemical agents. The figure below shows the ozone concetration over time for a facility. The green area exemplifies the range of ozone concentration applied on the process equipment. As can be seen below, the ozone contration increases over time and reaches adequate levels for disinfection in just a few minutes. The sanitation cycle is complete in 5-15 minutes depending on the amount of microorganisms and type. Since ozone is approximately 10-1000 times more effective than other chemicals against bacteria, mold and viruses, the sanitation can be ended in only a few minutes, saving important down-time for any type of facility. Typical target ozone concentration is 1 ppm for 3 log reduction of all types unwanted microorganisms in 15 minutes. Please read more about ozone disinfection mechanisms at our Disinfection application section.

Concept of in-situ ozone sanitation in CIP

The following video shows our RENA Vivo A-series as an integrated part of a CIP process, in the following example a brewery:

Clean-out-of-Place (COP)

While CIP refers to cleaning and sanitation of the interior of process equipment, COP refers to surface sanitation of tanks, pipes or floors. Typically, foaming agents are used to aid the visual inspection of cleaned versus non-cleaned areas. Ozone presents and opportunity to avoid exposure of chemicals during COP operations by employing an ozone system to produce ozone on demand and in-situ. Ozone use provides a clear indication since it leaves a gentle odor after use which is an indicator of successful sanitation.

Biofilm removal

Due to the strang disinfection power of ozone, existing biofilm can be removed by ozonating over an extended time period, allowing ozone to break down cell walls and organic material. Biofilm may occur in systems where insufficient sanitation or cleaning has allowed for biological growth of bacteria on organic material left from production. In such cases, ozone is an excellent way to remove the biofilm and prevent future growth.

Cooling towers and closed water systems

These types of applications differ in some respects from CIP applications. In closed cooling systems or cooling towers, large volumes of water circulate with very long hydraulic retention. In these instances, ozone concentrations below 0.2 ppm suffice to prevent microbial growth. With large hydraulic retention times, existing biofilm can be degraded effectively.

Applicable industries

Ozone sanitation of process equipment is especially valuable for breweries, dairy facilities, off-shore and food production. Food production also has an extended use in terms of rinse of fresh-produce.

Ozone tech